Pdcd4 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPdcd4 ELISA Kit for Rat(Rattus norvegicus)

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Pdcd4 (Gene name),

Programmed cell death protein 4 (Protein name ), PDCD4_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pdcd4(Dug);

Protein name:

Programmed cell death protein 4;

Alternative:

Death up-regulated gene protein;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

Function:

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.

Subcellular Location:

Nucleus Cytoplasm Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457.

Protein Attributes:

Sequence length:

469

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

469:

GRKRFVSEGD | GGRLKPESY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:64031

Pfam:

PF02847

UniGene:

Rn.206228

String:

Q9JID1

SMR:

Q9JID1

UniGene:

Rn.122017

Uniprot:

Q9JID1

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ELISA Kit for Rat Programmed cell death protein 4

Cat.:

E2393h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Programmed cell death protein 4

Cat.:

E2393c

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MSDS:

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Packing:

96T

ELISA Kit for Rat Programmed cell death protein 4

Cat.:

E2393m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Programmed cell death protein 4

Cat.:

E2393r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Programmed cell death protein 4

Cat.:

U2393r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Programmed cell death protein 4

Cat.:

U2393c

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MSDS:

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Packing:

96T

CLIA Kit for Rat Programmed cell death protein 4

Cat.:

U2393h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat Programmed cell death protein 4

Cat.:

U2393m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Programmed cell death protein 4

Cat.:

P2393Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Programmed cell death protein 4

Cat.:

P2393Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Programmed cell death protein 4

Cat.:

P2393Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Programmed cell death protein 4

Monoclonal Antibody for Rat Programmed cell death protein 4

Protein for Rat Programmed cell death protein 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"DUG is a novel homologue of translation initiation factor 4G that binds eIF4A."
Goeke A. , Goeke R. , Knolle A. , Trusheim H. , Schmidt H. , Wilmen A. , Carmody R. , Goeke B. , Chen Y.H.
Biochem. Biophys. Res. Commun.297:78-82(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;INTERACTION WITH EIF4A1;INDUCTION;ALTERNATIVE SPLICING
2.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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